MCI-INI-3 | ALDH1A3 inhibitor | Probechem Biochemicals

Chemical Structure : MCI-INI-3

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MCI-INI-3 (ALDH1A3 inhibitor)

货号: PC-72799Not For Human Use, Lab Use Only.

MCI-INI-3 is a potent, selective, competitive inhibitor of ALDH1A3 (Ki=0.55 uM, shows poor inhibitory effect on the structurally related isoform ALDH1A1 (>140-fold selectivity).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

MCI-INI-3 is a potent, selective, competitive inhibitor of ALDH1A3 (Ki=0.55 uM), shows poor inhibitory effect on the structurally related isoform ALDH1A1 (>140-fold selectivity).
MCI-INI-3 also displays on inhibition against six isoforms of ALDH (ALDH16A1, ALDH7A1, ALDH9A1, ALDH2, ALDH1B1, ALDH18A1).
MCI-INI-3 demonstrates selective binding to ALDH1A3 in glioma stem cell lysates, inhibits ALDH activity and affects RA synthesis in cells.

物理化学性质&存储条件

分子量	373.368
分子式	C21H15N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 5-(benzo[d][1,3]dioxol-5-yl)-2-phenylpyrazolo[1,5-a]pyrimidine-7-carboxylate

参考文献

1. Jianfeng Li, et al. Commun Biol. 2021 Dec 21;4(1):1420.