MC4762 | NOX2/MAOB inhibitor | Probechem Biochemicals

Chemical Structure : MC4762

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MC4762 (MC-4762, Compound 9a)

货号: PC-27683Not For Human Use, Lab Use Only.

MC4762 (Compound 9a) is a potent, dual covalent NOX2/MAOB inhibitor with IC50 of 0.155 uM, selectively inhibits monoamine oxidase B (MAOB over MAOA (465-fold) with IC50 of 0.182 uM.

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生物&药学活性

MC4762 (Compound 9a) is a potent, dual covalent NOX2/MAOB inhibitor with IC50 of 0.155 uM, selectively inhibits monoamine oxidase B (MAOB over MAOA (465-fold) with IC50 of 0.182 uM.
MC4762 decreased ROS production and downregulated proinflammatory cytokines as iNOS, IL-1β, and IL-6 expression in BV2 microglia neuroinflammation model.

物理化学性质&存储条件

分子量	441.51
分子式	C23H19N7OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((7-(Benzo[d]oxazol-2-ylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)methyl)benzyl)-N-methylprop-2-yn-1-amine

参考文献

1. Beatrice Noce, et al. J Med Chem. 2025 Mar 27;68(6):6292-6311.

MC4762 (MC-4762, Compound 9a)

生物&药学活性

物理化学性质&存储条件

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MC4762 (MC-4762, Compound 9a)

生物&药学活性

物理化学性质&存储条件

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