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首页-小分子抑制剂&激动剂-Epigenetics-Histone Demethylase-MC4455
MC4455

Chemical Structure : MC4455

CAS No.:

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MC4455 (MC-4455)

货号: PC-26539Not For Human Use, Lab Use Only.

MC4455 is a potent, selective dual LSD1/PRMT5 hybrid inhibitor with IC50 of 104/14 nM for LSD1/CoREST and PRMT5/MEP50, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MC4455 is a potent, selective dual LSD1/PRMT5 hybrid inhibitor with IC50 of 104/14 nM for LSD1/CoREST and PRMT5/MEP50, respectively.
    MC4455 binds covalently to the flavin adenine dinucleotide (FAD) cofactor of LSD1.
    MC4455 reduces SDMA levels similarly to GSK591 in MV4-11 cells, and increases H3K4me2 levels like GSK-LSD1.

    物理化学性质&存储条件

    分子量 457.58
    分子式 C27H31N5O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((4-((1S,2R)-2-aminocyclopropyl)phenyl)amino)-N-((S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)isonicotinamide

    参考文献

    1. Param NJ, et al. Sci Adv. 2026 Mar 27;12(13):eaea4059.

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