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首页-小分子抑制剂&激动剂-Epigenetics-Histone Demethylase-MC4455
MC4455

Chemical Structure : MC4455

CAS No.:

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MC4455 (MC-4455)

货号: PC-26539Not For Human Use, Lab Use Only.

MC4455 is a potent, selective dual LSD1/PRMT5 hybrid inhibitor with IC50 of 104/14 nM for LSD1/CoREST and PRMT5/MEP50, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MC4455 is a potent, selective dual LSD1/PRMT5 hybrid inhibitor with IC50 of 104/14 nM for LSD1/CoREST and PRMT5/MEP50, respectively.
MC4455 binds covalently to the flavin adenine dinucleotide (FAD) cofactor of LSD1.
MC4455 reduces SDMA levels similarly to GSK591 in MV4-11 cells, and increases H3K4me2 levels like GSK-LSD1.

物理化学性质&存储条件

分子量 457.58
分子式 C27H31N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((4-((1S,2R)-2-aminocyclopropyl)phenyl)amino)-N-((S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)isonicotinamide

参考文献

1. Param NJ, et al. Sci Adv. 2026 Mar 27;12(13):eaea4059.

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