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首页-小分子抑制剂&激动剂-Epigenetics-Sirtuin -MC3138
MC3138

Chemical Structure : MC3138

CAS No.: 1844889-12-8

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MC3138 (MC 3138)

货号: PC-49081Not For Human Use, Lab Use Only.

MC3138 is a potent and selective small-molecule SIRT5 activator, inhibits proliferation in SIRT5-low PDAC cell lines and organoids.

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10 mg ￥1480 In stock
25 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MC3138 is a potent and selective small-molecule SIRT5 activator, inhibits proliferation in SIRT5-low PDAC cell lines and organoids.
MC3138 reduces PDAC cell viability with IC50 of 25.4-236.9 uM.
MC3138 increased SIRT5 deacetylase activity 1.5-fold at 10 μM, 3-fold at 50 μM, and 4-fold at 200 μM.
MC3138 reduces PDAC cell viability with IC50 of 25.4-236.9 uM.
MC3138 mimicked the deacetylation effect mediated by SIRT5 overexpression, decreased lysine acetylation of the GOT1 protein and inhibited its enzymatic activity.
MC3138 decreased the metabolite levels in glutamine, glutathione, and pyrimidine metabolism pathways in SIRT5-low PDAC cell lines.
MC3138 combined with gemcitabine was synergistic at different concentrations in human PDAC organoids with low-SIRT5 expression.
MC3138 combined with gemcitabine significantly decreased tumor size, tumor weight, and tumor proliferation cell index in mice, significantly decreased GOT activity in the MC3138-treated tumors.

物理化学性质&存储条件

分子量 435.48
分子式 C25H25NO6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

diethyl 1-benzoyl-4-(3-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate

参考文献

1. Hu, Tuo, et al. Gastroenterology. 2021 Nov;161(5):1584-1600.

2. Francesco Fiorentino, et al. J Med Chem. 2022 Jul 8. doi: 10.1021/acs.jmedchem.2c00687.

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