MC2884 |CAS:330657-42-6 Probechem Biochemicals

Chemical Structure : MC2884

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MC2884 (MC 2884;MC-2884 )

货号: PC-35191Not For Human Use, Lab Use Only.

MC2884 is a novel hybrid, dual HAT/EZH2 inhibitor with IC50 of 3.27, 8.35 and 4.56 uM for CBP, KAT5 and p300, respectively.

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生物&药学活性

MC2884 is a novel hybrid, dual HAT/EZH2 inhibitor with IC50 of 3.27, 8.35 and 4.56 uM for CBP, KAT5 and p300, respectively.
MC2884 induces caspase- and mitochondrial-dependent cancer-selective apoptosis on a variety of cancers, accompanied by ROS production.
MC2884 displays anticancer action in both hematological and solid cancer in vivo models, induces apoptosis in aggressive cancers and in primary leukemic blasts, also synergizes with BCL2 inhibitors.

物理化学性质&存储条件

分子量	523.268
分子式	C26H21Br2NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-benzyl-3,5-bis((E)-3-bromobenzylidene)piperidin-4-one

参考文献

1. Petraglia F, et al. Oncotarget. 2018 May 22;9(39):25630-25646.

2. Singh AA, et al. Oncotarget. 2018 May 22;9(39):25647-25660.

MC2884 (MC 2884;MC-2884 )

生物&药学活性

物理化学性质&存储条件

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MC2884 (MC 2884;MC-2884 )

生物&药学活性

物理化学性质&存储条件

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