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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-MC2625
MC2625

Chemical Structure : MC2625

CAS No.: 1776116-75-6

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MC2625 (MC-2625)

货号: PC-27700Not For Human Use, Lab Use Only.

MC2625 is a potent histone deacetylase (HDAC) inhibitor, shows selective HDAC3 and HDAC6 inhibition with IC50 of 80 nM and 11 nM respectively, also potently reactivate HIV from latency with EC50 of 350 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MC2625 is a potent histone deacetylase (HDAC) inhibitor, shows selective HDAC3 and HDAC6 inhibition with IC50 of 80 nM and 11 nM respectively, also potently reactivate HIV from latency with EC50 of 350 nM.
MC2625 increases acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth.
MC2625 induces growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells (CSCs).

物理化学性质&存储条件

分子量 387.44
分子式 C23H21N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-3-(5-(2,3-diphenylpropanamido)pyridin-2-yl)-N-hydroxyacrylamide

参考文献

1. Di Pompo G, et al. J Med Chem. 2015 May 14;58(9):4073-9.

2. Heffern EF, et al. J Virus Erad. 2019 Apr 1;5(2):84-91.

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