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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-MC2590
MC2590

Chemical Structure : MC2590

CAS No.: 2284460-01-9

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MC2590 (MC-2590)

货号: PC-27698Not For Human Use, Lab Use Only.

MC2590 is a selective class I/IIb HDACs inhibitor with IC50 of 0.098, 0.156, 0.039, 0.015 and 0.047 uM for HDAC1, 2, 3, 6 and HDAC8 respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MC2590 is a selective class I/IIb HDACs inhibitor with IC50 of 0.098, 0.156, 0.039, 0.015 and 0.047 uM for HDAC1, 2, 3, 6 and HDAC8 respectively.
MC2590 weakly inhibits other HDAC isoforms HDAC4, HDAC5, HDAC7, HDAC9, HDAC11 with IC50s of 1.35-3.98 uM.
MC2590 induces cell cycle arrest modulating cell cycle-/apoptosis-related miRNAs expression in U937 cells.

物理化学性质&存储条件

分子量 347.37
分子式 C20H17N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-N-hydroxy-3-(5-(2-(naphthalen-1-yl)acetamido)pyridin-2-yl)acrylamide

参考文献

1. Elisabetta Di Bello, et al. Eur J Med Chem. 2022 Dec 15;247:115022.

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