MC1742 | HDAC inhibitor | Probechem Biochemicals

Chemical Structure : MC1742

CAS No.: 1776116-74-5

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MC1742 (MC-1742)

货号: PC-27699Not For Human Use, Lab Use Only.

MC1742 is a potent HDAC inhibitor with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively, also potently reactivate HIV from latency.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MC1742 is a potent HDAC inhibitor with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively, also potently reactivate HIV from latency with EC50 of 350 nM.
MC1742 increases acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth.
MC1742 induces growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells (CSCs).
MC1742 also blocks Toxoplasma gondii tachyzoite growth and profoundly disrupts parasite gene expression.

物理化学性质&存储条件

分子量	395.48
分子式	C21H21N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((4-([1,1'-Biphenyl]-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-hydroxypentanamide

参考文献

1. Di Pompo G, et al. J Med Chem. 2015 May 14;58(9):4073-9.

2. Mouveaux T, et al. Int J Antimicrob Agents. 2022 Mar;59(3):106526.

MC1742 (MC-1742)

生物&药学活性

物理化学性质&存储条件

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MC1742 (MC-1742)

生物&药学活性

物理化学性质&存储条件

参考文献

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