MBZM-N-IBT | CHIKV inhibitor | Probechem Biochemicals

Chemical Structure : MBZM-N-IBT

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MBZM-N-IBT (HIKV nsP2 protease inhibitor)

货号: PC-47106Not For Human Use, Lab Use Only.

MBZM-N-IBT is a small molecule inhibitor of Chikungunya virus (CHIKV), inhibits CHIKV infection in vitro in RAW 264.7 cells with IC50 of 22.34 uM, targets CHIKV nsP2 protease activity.

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生物&药学活性

MBZM-N-IBT is a small molecule inhibitor of Chikungunya virus (CHIKV), inhibits CHIKV infection in vitro in RAW 264.7 cells with IC50 of 22.34 uM, targets CHIKV nsP2 protease activity.
MBZM-N-IBT predominately interfered in the early stages of CHIKV life cycle, diminished the CHIKV-induced inflammatory responses in vitro through significant downregulation of all the major mitogen-activated protein kinases (MAPKs), NF-κB, cyclooxygenase (COX)-2, and cytokines.
MBZM-N-IBT restricted CHIKV infection and inflammation in vivo, leading to reduced clinical scores and complete survival of C57BL/6 mice.
MBZM-N-IBT also remarkably reduced CHIKV infection in hPBMC-derived monocyte-macrophage populations ex vivo.

物理化学性质&存储条件

分子量	364.427
分子式	C18H16N6OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-2-(1-((2-methyl-1H-benzo[d]imidazol-1-yl)methyl)-2-oxoindolin-3-ylidene)hydrazine-1-carbothioamide

参考文献

1. Saikat De, et al. Antimicrob Agents Chemother. 2022 Jun 29;e0046322.

MBZM-N-IBT (HIKV nsP2 protease inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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MBZM-N-IBT (HIKV nsP2 protease inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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