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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Influenza Virus-MBX2546
MBX2546

Chemical Structure : MBX2546

CAS No.: 695160-12-4

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MBX2546 (MBX 2546)

货号: PC-20584Not For Human Use, Lab Use Only.

MBX2546 is a small molecule inhibitor of influenza virus via targeting influenza hemagglutinin (HA), specifically inhibits HA-mediated viral entry with potent antiviral activity against different influenza virus strains (IC50=0.3-5.9 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MBX2546 is a small molecule inhibitor of influenza virus via targeting influenza hemagglutinin (HA), specifically inhibits HA-mediated viral entry with potent antiviral activity against different influenza virus strains (IC50=0.3-5.9 uM).
MBX2546 binds to HA in a nonoverlapping manner, binds to the group 1 HA-specific conformational epitope in the HA stem region.
MBX2546 displays little inhibitory activity against HIV/LASV-GP, HIV/EBOV-GP, or HIV/VSV-G with IC50 values >100 uM.
MBX2546 inhibitsinfluenza A H1N1 virus strains A/PR/8/34 (H1N1) and A/Florida/21/2008 (H1N1-H275Y) (oseltamivir-resistant strain) with IC50s of 0.3 μM and 5.8 μM, respectively.
MBX2546 also inhibits other H1N1 strains, including A/California/10/2009/H1N1 (2009 pandemic strain), with IC50s of between 0.55 μM and 1.5 μM.
MBX2546 displays significantly less activity against influenza A H3N2 virus strain A/Texas/12/2007 (H3N2) and influenza B virus strain B/Florida/4/2006.
MBX2546 specifically inhibits influenza viruses of group 1 HA (H1 and H5 subtypes), but not group 2 HA (H3 and H7 subtypes).
MBX2546 exhibit strong synergy with oseltamivir.

物理化学性质&存储条件

分子量 391.44
分子式 C18H21N3O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(NC1=CC(C)=CC(C)=C1)CN(S(=O)(C)=O)C2=CC([N+]([O-])=O)=CC=C2C

参考文献

1. Basu A, et al. J Virol. 2014 Feb;88(3):1447-60.

2. Basu A, et al. ACS Infect Dis. 2017 May 12;3(5):330-335.

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