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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-PPAR-MBX-102 acid
MBX-102 acid

Chemical Structure : MBX-102 acid

CAS No.: 23953-39-1

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MBX-102 acid (MBX102 acid)

货号: PC-49253Not For Human Use, Lab Use Only.

MBX-102 acid is the active form of JNJ39659100 (MBX-102), a selective partial PPAR-γ agonist with EC50 of 23.34 uM (hPPAR-γ), enhances insulin sensitivity in vitro in 3T3-L1 adipocytes, binds to the PPAR-γ LBD in a manner that is distinct from but overlapping with rosiglitazone.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MBX-102 acid is the active form of JNJ39659100 (MBX-102), a selective partial PPAR-γ agonist with EC50 of 23.34 uM (hPPAR-γ), enhances insulin sensitivity in vitro in 3T3-L1 adipocytes, binds to the PPAR-γ LBD in a manner that is distinct from but overlapping with rosiglitazone.

    物理化学性质&存储条件

    分子量 330.687
    分子式 C15H10ClF3O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-2-(4-chlorophenyl)-2-(3-(trifluoromethyl)phenoxy)acetic acid

    参考文献

    1. Gregoire FM, et al. Mol Endocrinol. 2009 Jul;23(7):975-88.

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