MBP-11901 | Multikinase inhibitor | Probechem Biochemicals

Chemical Structure : MBP-11901

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MBP-11901 (MBP11901)

货号: PC-47032Not For Human Use, Lab Use Only.

MBP-11901 is an orally active, multitarget tyrosine kinase inhibitor targeting FLT3, VEGFR2, PDGFRβ, and c-KIT, shows excellent inhibitory activity against HCC cell growth in vitro (HepG2, IC50=5.16 uM).

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生物&药学活性

MBP-11901 is an orally active, multitarget tyrosine kinase inhibitor targeting FLT3, VEGFR2, PDGFRβ, and c-KIT, shows excellent inhibitory activity against HCC cell growth in vitro (HepG2, IC50=5.16 uM).
MBP-11901 induces apoptosis and inhibits cell migration and invasion of HepG2 cells.
MBP-11901 binds selectively and tightly to FLT3, MAP4K2, KIT, VEGFR2, and PDGFRβ with Kd values of 295, 1100, 3850, 3550, and 4000 nM, respectively.
MBP-11901 was effective against various human HCC cell lines, leading to the disappearance of most tumors when administered orally in animal models.

物理化学性质&存储条件

分子量	312.391
分子式	C16H16N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,3-diamino-N-(4-(benzo[d]thiazol-2-yl)phenyl)propanamide

参考文献

1. Park HJ, et al. Cancers (Basel). 2022 Apr 14;14(8):1994.

MBP-11901 (MBP11901)

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物理化学性质&存储条件

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MBP-11901 (MBP11901)

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