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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Hec1/Nek2-MBM-55S
MBM-55S

Chemical Structure : MBM-55S

CAS No.: 2083624-07-9

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MBM-55S (MBM-55 succinic acid salt)

货号: PC-27600Not For Human Use, Lab Use Only.

MBM-55S (MBM-55 succinic acid salt) is a potent, selective NIMA-related kinase 2 (NEK2) inhibitor with IC50 of 1.0 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MBM-55S (MBM-55 succinic acid salt) is a potent, selective NIMA-related kinase 2 (NEK2) inhibitor with IC50 of 1.0 nM.
MBM-55 effectively inhibits proliferation of MGC-803 cells with IC50 of 0.53 uM.
MBM-55 induces G2/M phase arrest and accumulation of cells in HCT-116 and MGC-803 cells.
MBM-55 triggers apoptosis of cancer cells.

物理化学性质&存储条件

分子量 616.65
分子式 C32H33FN6O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(7-(1-(2-(Dimethylamino)ethyl)-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)-2-((3-fluorobenzyl)oxy)benzamide succinic acid salt

参考文献

1. Xi JB, et al. Eur J Med Chem. 2017 Jan 27;126:1083-1106.

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