MBL inhibitor 58 | Metallo-β-lactamase inhibitor | Probechem Biochemicals

Chemical Structure : MBL inhibitor 58

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MBL inhibitor 58 (InCs compound 58)

货号: PC-72815Not For Human Use, Lab Use Only.

MBL inhibitor 58 (InCs compound 58) is a potent broad-spectrum metallo-β-lactamase (MBL inhibitor), active against all MBL classes of major clinical relevance

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生物&药学活性

MBL inhibitor 58 (InCs compound 58) is a potent broad-spectrum metallo-β-lactamase (MBL inhibitor), active against all MBL classes of major clinical relevance.
InCs compound 58 restores carbapenem activity against multiple drug-resistant Gram-negative bacteria and has a low frequency of resistance.
InCs compound 58 also have a good in vivo safety profile, and when combined with meropenem show a strong in vivo efficacy in peritonitis and thigh mouse infection models.

物理化学性质&存储条件

分子量	529.583
分子式	C26H28FN3O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((S)-1-((2S,4r)-2-(aminomethyl)-6-oxo-5-oxa-7-azaspiro[3.4]octan-7-yl)ethyl)-3-(3-fluoro-4-((methylsulfonyl)methyl)phenyl)-1H-indole-2-carboxylic acid

参考文献

1. Jürgen Brem, et al. Nat Chem. 2022 Jan;14(1):15-24.

MBL inhibitor 58 (InCs compound 58)

生物&药学活性

物理化学性质&存储条件

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MBL inhibitor 58 (InCs compound 58)

生物&药学活性

物理化学性质&存储条件

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