MBD2 inhibitor APC

Chemical Structure : MBD2 inhibitor APC

CAS No.: 1353960-31-2

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货号: PC-72568Not For Human Use, Lab Use Only.

MBD2 inhibitor APC (APC) is a small molecule inhibitor targeting an intrinsically disordered protein region (IDPR) of MBD2 with antimetastatic activity, inhibits DOT-mediated PPI of MBD2, efficiently disrupts MBD2 interaction with p66α with IC50 of 1.03 uM (FRET).

规格	价格	库存
10 mg	￥1580	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

MBD2 inhibitor APC (APC) is a small molecule inhibitor targeting an intrinsically disordered protein region (IDPR) of MBD2 with antimetastatic activity, inhibits DOT-mediated PPI of MBD2, efficiently disrupts MBD2 interaction with p66α with IC50 of 1.03 uM (FRET).
APC suppresses the migration of breast adenocarcinoma MDA-MB-231 (LM1) and colorectal carcinoma HCT116 cells.
APC induces mesenchymal-epithelial transition (MET) on treatment of mesenchymal type of cancer cells.
APC exhibits a potent inhibition of the cancer metastasis to lung in xenograft mice transplanted with the LM1 cells, with no significant effects on body weight.

物理化学性质&存储条件

分子量	243.307
分子式	C11H21N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-amino-acetylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester

参考文献

1. Min Young Kim, et al. Sci Adv. 2019 Nov 20;5(11):eaav9810.