MBD2 inhibitor ABA

Chemical Structure : MBD2 inhibitor ABA

CAS No.: 1247158-03-7

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货号: PC-72567Not For Human Use, Lab Use Only.

MBD2 inhibitor ABA (ABA) is a small molecule inhibitor targeting an intrinsically disordered protein region (IDPR) of MBD2 with antimetastatic activity, inhibits DOT-mediated PPI of MBD2, efficiently disrupts MBD2 interaction with p66α with IC50 of 1.4 uM (FRET).

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MBD2 inhibitor ABA (ABA) is a small molecule inhibitor targeting an intrinsically disordered protein region (IDPR) of MBD2 with antimetastatic activity, inhibits DOT-mediated PPI of MBD2, efficiently disrupts MBD2 interaction with p66α with IC50 of 1.4 uM (FRET).
ABA suppresses the migration of breast adenocarcinoma MDA-MB-231 (LM1) and colorectal carcinoma HCT116 cells.
ABA induces mesenchymal-epithelial transition (MET) on treatment of mesenchymal type of cancer cells.
ABA exhibits a potent inhibition of the cancer metastasis to lung in xenograft mice transplanted with the LM1 cells, with no significant effects on body weight.

物理化学性质&存储条件

分子量	222.244
分子式	C11H14N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-N-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-acetamide

参考文献

1. Min Young Kim, et al. Sci Adv. 2019 Nov 20;5(11):eaav9810.