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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Nucleoside Antimetabolite/Analog-MB07133
MB07133

Chemical Structure : MB07133

CAS No.: 685111-92-6

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MB07133 (Zefoscytarabine, MB7133, MB-7133, MB-07133)

货号: PC-27515Not For Human Use, Lab Use Only.

Zefoscytarabine (MB-7133, MB07133) is a liver-targeted prodrug of cytarabine mononucleotide (araCMP) and a DNA polymerase inhibitor inhibits DNA synthesis, selectively releases the monophosphate of a nucleoside (NMP) into CYP3A4-expressing cells, such as hepatocytes.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Zefoscytarabine (MB-7133, MB07133) is a liver-targeted prodrug of cytarabine mononucleotide (araCMP) and a DNA polymerase inhibitor inhibits DNA synthesis, selectively releases the monophosphate of a nucleoside (NMP) into CYP3A4-expressing cells, such as hepatocytes.

物理化学性质&存储条件

分子量 440.35
分子式 C17H21N4O8P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2(1H)-Pyrimidinone, 4-amino-1-[5-O-[(2R,4S)-2-oxido-4-(4-pyridinyl)-1,3,2-dioxaphosphorinan-2-yl]-β-D-arabinofuranosyl]-

参考文献

1. Erion MD, et al. J Pharmacol Exp Ther. 2005 Feb;312(2):554-60.

2. Boyer SH, et al. J Med Chem. 2006 Dec 28;49(26):7711-20.

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