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首页-小分子抑制剂&激动剂-Tyrosine Kinase-FGFR-MAX-40279
MAX-40279

Chemical Structure : MAX-40279

CAS No.: 2070931-57-4

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MAX-40279 (MAX40279, EX-A4057)

货号: PC-72411Not For Human Use, Lab Use Only.

MAX-40279 (MAX40279, EX-A4057) is a dual inhibitor of FLT3 and FGFR for the treatment of Acute Myeloid Leukemia (AML).

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5 mg ￥2480 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MAX-40279 (MAX40279, EX-A4057) is a dual inhibitor of FLT3 and FGFR for the treatment of Acute Myeloid Leukemia (AML).
MAX-40279 demonstrated potent inhibition of both FLT3 and FGFR with excellent drug concentration in the bone marrow.
MAX-40279 is designed to overcome the observed drug resistance of the current FLT3 inhibitors due to the bone marrow FGF/FGFR pathway activation.

物理化学性质&存储条件

分子量 438.525
分子式 C22H23FN6OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Thieno[3,2-d]pyrimidin-2-amine, 7-(4-fluoro-2-methoxyphenyl)-6-methyl-N-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

参考文献

1. Patent WO2021180032A1.

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