MAT2A inhibitor ZS34

Chemical Structure : MAT2A inhibitor ZS34

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货号: PC-27512Not For Human Use, Lab Use Only.

MAT2A inhibitor ZS34 is a potent, selective, and orally bioavailable MAT2A inhibitor with IC50 of 13.7 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MAT2A inhibitor ZS34 is a potent, selective, and orally bioavailable MAT2A inhibitor with IC50 of 13.7 nM.
ZS34 selectively suppresses the growth of MTAP-deficient cancer cells (HCT116 MTAP+, IC50=124 nM), but not HCT116 MTAP- cancel cells.
ZS34 demonstrates on-target engagement in MTAP-deficient cells, as evidenced by inhibition of SAM synthesis, reduction of SDMA levels, and induction of DNA damage.
ZS34 displays minimal hERG and UGT1A1 liabilities along with favorable oral pharmacokinetics.
ZS34 (10-50 mg/kg, po/qd) demonstrates significant antitumor efficacy without obvious toxicity in HCT116 MTAP–/– xenograft mouse model.

物理化学性质&存储条件

分子量	339.78
分子式	C18H14ClN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-9-(methylamino)-6-(o-tolyl)furo[2,3-f]quinazolin-7(6H)-one

参考文献

1. Patent WO2022256808 A1 2022-12-08.

2. Zihan Shi, et al. J Med Chem. 2025 Nov 27;68(22):24213-24231.