MAT-POS-e194df51-1

Chemical Structure : MAT-POS-e194df51-1

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货号: PC-21335Not For Human Use, Lab Use Only.

MAT-POS-e194df51-1 is potent, selective and noncovalent SARS-CoV-2 main protease (SARS-CoV-2 Mpro) inhibitor with IC50 of 36.8 nM, shows antiviral activity with EC50 of 64 nM in A549-ACE2-TMPRSS2 cells.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

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生物&药学活性

MAT-POS-e194df51-1 is potent, selective and noncovalent SARS-CoV-2 main protease (SARS-CoV-2 Mpro) inhibitor with IC50 of 36.8 nM, shows antiviral activity with EC50 of 64 nM in A549-ACE2-TMPRSS2 cells.
MAT-POS-e194df51-1 shows good cross-reactivity against known circulating variants of SARS-CoV-2 in antiviral cellular assays in a CPE assay in HeLa-ACE2 cells, including SARS-CoV-2 variants Alpha, Beta, Delta, and Omicron.
MAT-POS-e194df51-1 shows antiviral activity EC50 of 126 nM in HeLa-ACE2 cells without measurable cytotoxicity.
MAT-POS-e194df51-1 shows the distinct Mpro binding site compared to approved Mpro inhibitors nirmatrelvir and ensitrelvir (S-217622).
MAT-POS-e194df51-1 exhibits favorable properties required for an orally bioavailable inhibitor.

物理化学性质&存储条件

分子量	480.97
分子式	C24H21ClN4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-6-chloro-2-(((1-cyanocyclopropyl)methyl)sulfonyl)-N-(isoquinolin-4-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide

参考文献

1. Melissa L Boby, et al. Science. 2023 Nov 10;382(6671):eabo7201.