MASM7 | Mitofusin activator | Probechem Biochemicals

Chemical Structure : MASM7

CAS No.: 920868-45-7

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MASM7 (Mitofusin activator MASM7)

货号: PC-49094Not For Human Use, Lab Use Only.

MASM7 is a small molecule activator of mitochondrial fusion via mitofusins (MFN1 and MFN2), concentration-responsively increases mitochondrial aspect ratio (Mito AR) in MEFs with EC50 of 75 nM, directly and specifically modulates MFN1/2 fusogenic activity.

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10 mg	￥2480	In stock
25 mg	￥4280	In stock
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生物&药学活性

MASM7 is a small molecule activator of mitochondrial fusion via mitofusins (MFN1 and MFN2), concentration-responsively increases mitochondrial aspect ratio (Mito AR) in MEFs with EC50 of 75 nM, directly and specifically modulates MFN1/2 fusogenic activity.
MASM7 showed more potent induction of mitochondrial fusion in cells than the 367-384Gly peptide (EC50=340 nM).
MASM7 directly and specifically interacts with the HR2 domain of MFN2 with Kd of 1.1 uM in microscale thermophoresis (MST) assays, does not bind to MFN2-HR2 D725A/L727A mutants.
MASM7 induces stabilization of MFN2 in cellular extract thermal shift assay (CETSA), but not of L727A Mfn2 mutant, does not alter Mfn1 and Mfn2 gene expression and their corresponding protein levels.
MASM7 increases basal and maximal respiration and mitochondrial ATP production in WT but not in Mfn1/Mfn2 DKO MEFs.
MASM7 can activate both MFN2 and MFN1.

物理化学性质&存储条件

分子量	453.579
分子式	C22H23N5O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-((5-cyclopropyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)propanamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide

参考文献

1. Zacharioudakis E, et al. Nat Commun. 2022 Jul 7;13(1):3775.

MASM7 (Mitofusin activator MASM7)

生物&药学活性

物理化学性质&存储条件

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MASM7 (Mitofusin activator MASM7)

生物&药学活性

物理化学性质&存储条件

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