MARPIN |CAS:848675-17-2 Probechem Biochemicals

Chemical Structure : MARPIN

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MARPIN

货号: PC-62037Not For Human Use, Lab Use Only.

MARPIN is a novel ATR-Chk1 pathway inhibitor that inhibits hydroxyurea (HU)-induced phosphorylation of Ser345 on Chk1 with IC50 of 7.7 uM.

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生物&药学活性

MARPIN is a novel ATR-Chk1 pathway inhibitor that inhibits hydroxyurea (HU)-induced phosphorylation of Ser345 on Chk1 with IC50 of 7.7 uM.
MARPIN inhibits ATR-selective phosphorylation and sensitizes p53-deficient cancer cells to DNA-damaging agents.
MARPIN does not inhibit ATR catalytic activity in vitro, but acts in a mechanistically distinct manner to disable ATR-Chk1 function.
MARPIN shows synergistic effect with cisplatin in xenograft model.

物理化学性质&存储条件

分子量	405.425
分子式	C24H20FNO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl (1R,6aR)-2-benzoyl-1-(4-fluorobenzyl)-6-methylene-5-oxo-1,2,3,5,6,6a-hexahydrocyclopenta[c]pyrrole-1-carboxylate

参考文献

1. Huryn DM, et al. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6757-62.

2. Kawasumi M, et al. Cancer Res. 2014 Dec 15;74(24):7534-45.

MARPIN

生物&药学活性

物理化学性质&存储条件

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MARPIN

生物&药学活性

物理化学性质&存储条件

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