MAP4K4 inhibitor 15f

Chemical Structure : MAP4K4 inhibitor 15f

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货号: PC-26554Not For Human Use, Lab Use Only.

MAP4K4 inhibitor 15f is a potent, selective inhibitor of MAP4K4 with IC50 of 89 nM, shows neuroprotective effects.

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250 mg		Get quote

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生物&药学活性

MAP4K4 inhibitor 15f is a potent, selective inhibitor of MAP4K4 with IC50 of 89 nM, shows neuroprotective effects.
MAP4K4 inhibitor 15f increased the viability of motor neurons in a dose-dependent manner.
MAP4K4 inhibitor 15f reduced the c-Jun phosphorylation level in a dose-dependent manner on SOD1 mutant ALS patient-derived iPSC-MNs.

物理化学性质&存储条件

分子量	343.32
分子式	C14H12F3N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-methyl-5-(4-(trifluoromethyl)phenyl)-3-ureidothiophene-2-carboxamide

参考文献

1. Hattori H, et al. Bioorg Med Chem Lett. 2024 Nov 15;113:129935.