MAP3K1 inhibitor 51-106 (iMAP3K1)

Chemical Structure : MAP3K1 inhibitor 51-106

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货号: PC-24647Not For Human Use, Lab Use Only.

MAP3K1 inhibitor 51-106 (iMAP3K1) is a selective MAP3K1 inhibitor with IC50 of 1.8 uM in in MAP3K1 WT cells, binds to MAP3K1 and blocks IKKβ phosphorylation, resulting in the inhibition of TNF-α-induced NF-κB activation.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MAP3K1 inhibitor 51-106 (iMAP3K1) is a selective MAP3K1 inhibitor with IC50 of 1.8 uM in in MAP3K1 WT cells, binds to MAP3K1 and blocks IKKβ phosphorylation, resulting in the inhibition of TNF-α-induced NF-κB activation.
51-106 does not inhibit MAP3K6 or MAP3K15 and inhibited MAP3K2, MAP3K3, MAP3K4, and MAP3K5 at a low level (4.6%, 11.4%, 8.6%, and 11.7%, respectively, at 5 uM).
51-106 also does not inhibit MAP3K1 substrates IKKβ and MAP2K4.

物理化学性质&存储条件

分子量	430.37
分子式	C20H14F4N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)urea

参考文献

1. Patent WO 2011/135376 A1, 2011.

2. Boghean L, et al. Molecules. 2025 Apr 30;30(9):2001.