MAP3K14-IN-173 |CAS:2113617-02-8 Probechem Biochemicals

Chemical Structure : MAP3K14-IN-173

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MAP3K14-IN-173 (MAP3K14 inhibitor, NIK inhibitor)

货号: PC-60165Not For Human Use, Lab Use Only.

MAP3K14-IN-173 is a novel potent MAP3K14 kinase (NF-κB-inducing kinase, NIK) inhibitor with IC50 of 1.8 nM (NIK autophosphorylation).

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生物&药学活性

MAP3K14-IN-173 is a novel potent MAP3K14 kinase (NF-κB-inducing kinase, NIK) inhibitor with IC50 of 1.8 nM (NIK autophosphorylation).
MAP3K14-IN-173 inhibits p-IKKα levels of L363 (NIK translocated multiple myeloma) cells with IC50 of 1.3 nM.
MAP3K14-IN-173 exhibits antiproliferative activity on JJN-3 (NIK translocated) multiple myeloma cells (IC50=29 nM).

物理化学性质&存储条件

分子量	509.614
分子式	C29H31N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-(2-((5-cyano-2-methyl-4-(2-morpholinoethyl)phenyl)amino)pyrimidin-4-yl)-3-(hydroxymethyl)-3-methylindoline-7-carbonitrile

参考文献

1. Kargbo RB, et al. ACS Med Chem Lett. 2017 Aug 17;8(9):908-910.

2. Patent WO2017125530 A1, compound example 173.

MAP3K14-IN-173 (MAP3K14 inhibitor, NIK inhibitor)

生物&药学活性

物理化学性质&存储条件

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MAP3K14-IN-173 (MAP3K14 inhibitor, NIK inhibitor)

生物&药学活性

物理化学性质&存储条件

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