MAO B inhibitor compound 1

Chemical Structure : MAO B inhibitor compound 1

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货号: PC-26555Not For Human Use, Lab Use Only.

MAO B inhibitor compound 1 is a potent, BBB-penetrant monoamine oxidase B (MAO B, MAO-B) inhibitor with IC50 of 52 nM, shows antioxidant and neuroprotective properties.

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生物&药学活性

MAO B inhibitor compound 1 is a potent, BBB-penetrant monoamine oxidase B (MAO B, MAO-B) inhibitor with IC50 of 52 nM, shows antioxidant and neuroprotective properties.
MAO B inhibitor compound 1 shows low activity toward MAO A (14% inhibition at 10 μM concentration, IC50 > 10 μM).

物理化学性质&存储条件

分子量	458.47
分子式	C25H22N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(1H-indazol-5-yl)-3-(4-((3,4,5-trimethoxybenzyl)oxy)phenyl)-1,2,4-oxadiazole

参考文献

1. Mastrogiacomo R, et al. Mol Pharm. 2026 Apr 10. doi: 10.1021/acs.molpharmaceut.5c01754.