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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Monoamine Oxidase (MAO)-MAO-B inhibitor 8f
MAO-B inhibitor 8f

Chemical Structure : MAO-B inhibitor 8f

CAS No.: 947540-06-9

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MAO-B inhibitor 8f

货号: PC-61487Not For Human Use, Lab Use Only.

MAO-B inhibitor 8f is a potent, selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 29-56 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MAO-B inhibitor 8f is a potent, selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 29-56 nM.
    MAO-B inhibitor 8f shows no significant activity over MAO-A (>10 uM).
    MAO-B inhibitor 8f shows improvement for memory in multiple animal models, has an excellent profile against a panel of other enzymes and receptors, good pharmacokinetic properties in rodents and dogs.

    物理化学性质&存储条件

    分子量 359.367
    分子式 C15H16F3N3O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4-hydroxypiperidin-1-yl)(5-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)thiophen-2-yl)methanone

    参考文献

    1. Kaplan A, et al. ACS Chem Neurosci. 2017 Dec 20;8(12):2746-2758.

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