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首页-小分子抑制剂&激动剂-NF-κB Pathway-MALT1-MALT1 inhibitor MI-2
MALT1 inhibitor MI-2

Chemical Structure : MALT1 inhibitor MI-2

CAS No.: 1047953-91-2

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MALT1 inhibitor MI-2 (MI 2;MI2)

货号: PC-42938Not For Human Use, Lab Use Only.

MALT1 inhibitor MI-2 is a selective, irreversible MALT1 paracaspase inhibitor with IC50 of 5.84 uM, displays little activity against the related caspase family members caspase-3, -8, and -9.

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25 mg ￥1880 In stock
50 mg ￥2880 In stock
100 mg ￥4580 In stock
200 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MALT1 inhibitor MI-2 is a selective, irreversible MALT1 paracaspase inhibitor with IC50 of 5.84 uM, displays little activity against the related caspase family members caspase-3, -8, and -9.
MALT1 inhibitor MI-2 inhibits cleavage of MALT1 substrates, which is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation.
MALT1 inhibitor MI-2 specifically suppresses ABC-DLBCL in vitro and in vivo.
MALT1 inhibitor MI-2 exhibits GI 50 of 0.2, 0.5, 0.4, and 0.4 uM for HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells respectively, inhibits nuclear translocation of RelB and p50, and decreases Bcl-xL levels in CLL cells.

物理化学性质&存储条件

分子量 455.7223
分子式 C19H17Cl3N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 46 mg/mL
Chemical Name/SMILES

Acetamide, 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenyl]-

参考文献

1. Fontan L, et al. Cancer Cell. 2012 Dec 11;22(6):812-24.

2. Saba NS, et al. Cancer Res. 2017 Dec 15;77(24):7038-7048.

3. Liu W, et al. Oncotarget. 2016 May 24;7(21):30536-49.

4. Yeh CN, et al. Oncotarget. 2017 Dec 8;8(69):113444-113459.

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