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首页-小分子抑制剂&激动剂-Others-Other Targets-MAI-400
MAI-400

Chemical Structure : MAI-400

CAS No.: 2250328-65-3

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MAI-400 (MAI400, MAI 400)

货号: PC-35569Not For Human Use, Lab Use Only.

MAI-400 (MAI400) is a novel peptide inhibitor of APC-Asef interaction with Kd of 12 nM and IC50 of 0.25 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MAI-400 (MAI400) is a novel peptide inhibitor of APC-Asef interaction with Kd of 12 nM and IC50 of 0.25 uM.
    MAI-400 effectively blocks the APC-Asef interaction in cell lysates in a dose-dependent manner.
    MAI-400 decreases the association of cellular APC protein with cellular Asef in a dose-dependent manner.

    物理化学性质&存储条件

    分子量 900.94
    分子式 C41H56N8O15
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4S,7S,10S,13S,16S)-16-(2-((S)-2-(((benzyloxy)carbonyl)amino)propanamido)acetamido)-4-carbamoyl-7-(4-hydroxybenzyl)-13-(hydroxymethyl)-10-isobutyl-6,9,12,15-tetraoxo-5,8,11,14-tetraazanonadecanedioic acid

    参考文献

    1. Yang X, et al. J Med Chem. 2018 Aug 10. doi: 10.1021/acs.jmedchem.8b01112.

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