MAGL inhibitor 4f | MAGL inhibitor | Probechem Biochemicals

Chemical Structure : MAGL inhibitor 4f

CAS No.: 2135785-20-3

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MAGL inhibitor 4f (T-211)

货号: PC-23496Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥2980	In stock
10 mg	￥4580	In stock
25 mg	￥7880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MAGL inhibitor 4f (T-211) is a potent, brain-penetrant reversible monoacylglycerol (MAGL) inhibitor with IC50 of 6.2 nM and 13 nM for human and mouse MAGL respectively, with high selectivity over FAAH and ABHD6 (IC50 > 10,000 nM).
MAGL inhibitor 4f (T-211) (1 mg/kg) robustly increased 2-arachidonoylglycerol levels and decreased arachidonic acid levels in the mouse brain.
MAGL inhibitor 4f (T-211) (1 mg/kg) significantly decreased the cytokine and chemokine expression levels and suppressed neuronal cell loss in the hippocampi of kainic acid (KA)-injected mice.
MAGL inhibitor 4f (T-211) also ameliorated cognitive impairment in KA-injected mice.

物理化学性质&存储条件

分子量	364.83
分子式	C18H21ClN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2s,4s)-2-(3-((3-chloro-4-methylbenzyl)oxy)azetidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one

参考文献

1. Arimura N, et al. PLoS One. 2024 Nov 21;19(11):e0312090.

2. Hattori Y, et al. J Med Chem. 2019 Mar 14;62(5):2362-2375.

MAGL inhibitor 4f (T-211)

生物&药学活性

物理化学性质&存储条件

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MAGL inhibitor 4f (T-211)

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物理化学性质&存储条件

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