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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-MAC13243
MAC13243

Chemical Structure : MAC13243

CAS No.: 1071638-38-4

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MAC13243 (MAC 13243)

货号: PC-20585Not For Human Use, Lab Use Only.

MAC13243 is a small molecule inhibitor of the bacterial lipoprotein targeting chaperone LolA (Kd=7.5 uM), exhibits potent Gram-negative antibacterial activity with MIC value of 4 ug/mL (Pseudomonas aeruginosa PA01).

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25 mg ￥7980 In stock
100 mg ￥17800 In stock
200 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MAC13243 is a small molecule inhibitor of the bacterial lipoprotein targeting chaperone LolA (Kd=7.5 uM), exhibits potent Gram-negative antibacterial activity with MIC value of 4 ug/mL (Pseudomonas aeruginosa PA01).
MAC13243 inhibits the function of the LolA protein and represents a new chemical probe of lipoprotein targeting in bacteria with promise as an antibacterial lead with Gram-negative selectivity.
MAC13243 exhibits promising activity against multidrug-resistant Pseudomonas aeruginosa.

物理化学性质&存储条件

分子量 442.40
分子式 C20H25Cl2N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

COC1=CC=C(CCN2CNC(SCC3=CC=C(Cl)C=C3)=NC2)C=C1OC.[H]Cl

参考文献

1. Pathania R, et al. Nat Chem Biol. 2009 Nov;5(11):849-56.

2. Barker CA, et al. Bioorg Med Chem Lett. 2013 Apr 15;23(8):2426-31.

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