MAC-545496 | GraR inhibitor | Probechem Biochemicals

Chemical Structure : MAC-545496

CAS No.: 838810-96-1

加入收藏

MAC-545496 (MAC545496)

货号: PC-72426Not For Human Use, Lab Use Only.

MAC-545496 (MAC545496) is an antivirulence compound that reverses β-lactam resistance in the community-acquired MRSA USA300 strain via inhibition on GraR function (Kd<0.1 nM).

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1680	In stock
50 mg	￥2680	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MAC-545496 (MAC545496) is an antivirulence compound that reverses β-lactam resistance in the community-acquired MRSA USA300 strain via inhibition on GraR function (Kd<0.1 nM).
MAC-545496 could also serve as an antivirulence agent alone.
MAC-545496 attenuates MRSA virulence in Galleria mellonella larvae.
MAC-545496 inhibits biofilm formation and abrogates intracellular survival in macrophages.
GraR is a regulator that responds to cell-envelope stress and is an important virulence factor and determinant of antibiotic resistance.
MAC-545496 has value as a research tool to probe the GraXRS regulatory system and as an antibacterial lead series of a mechanism to combat drug-resistant Staphylococcal infections.

物理化学性质&存储条件

分子量	419.884
分子式	C18H18ClN5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide

参考文献

1. Omar M El-Halfawy, et al. Nat Chem Biol. 2020 Feb;16(2):143-149.

MAC-545496 (MAC545496)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MAC-545496 (MAC545496)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.