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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-MAC-0452936
MAC-0452936

Chemical Structure : MAC-0452936

CAS No.: 257863-06-2

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MAC-0452936 (MAC0452936)

货号: PC-23136Not For Human Use, Lab Use Only.

MAC-0452936 is a specific small molecule inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli, with IC50 of 1.45 uM (DDM-Lgt).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MAC-0452936 is a specific small molecule inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli, with IC50 of 1.45 uM (DDM-Lgt).
MAC-0452936 inhibits Lgt activity with an IC50 of 0.59 μM and 1.45 μM for Lgt purified using amphipol and DDM lipid matrices, respectively.
MAC-0452936 inhibits the growth of E. coli through inhibition of Lgt.
MAC-0452936 demonstrates potent activity against wild-type isolates of E. coli and S. Tm when combined with the antibiotic adjuvant SPR741, but not Gram-negative pathogens A. baumannii, K. pneumoniae, K. aerogenes, or P. aeruginosa.

物理化学性质&存储条件

分子量 317.40
分子式 C17H19NO3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,2-Dimethyl-1-(2-thienyl)-1-propanone O-(4-methoxybenzoyl)oxime

参考文献

1. Rachwalski K, et al. iScience. 2024 Sep 5;27(10):110894.

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