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首页-抗体和重组蛋白-Biosimilar Antibody-M7824
M7824

Chemical Structure : M7824

CAS No.:

M7824 (Anti-human PD-L1&TGF-β mAb, human IgG1-Kappa)

货号: PC-Ab1007Not For Human Use, Lab Use Only.

Bintrafusp alfa (M7824), a bifunctional fusion protein targeting TGF-β and PD-L1, attenuated features of TGF-β1-mediated mesenchymalization, including mesenchymal marker expression, proliferation suppression, and chemoresistance in vitro and in vivo..

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Bintrafusp alfa (M7824), a bifunctional fusion protein targeting TGF-β and PD-L1, attenuated features of TGF-β1-mediated mesenchymalization, including mesenchymal marker expression, proliferation suppression, and chemoresistance in vitro and in vivo.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives

Chemical Name/SMILES

M7824; MSB0011359C; MSB 0011359C; Bintrafusp alfa; Anti-human PD-L1; programmed death 1 Ligand; Anti-human TGFBR2 (Transforming Growth Factor Beta Receptor 2); PD-L1, TGFβR2 bispecific

参考文献

1. 1, Knudson KM, et al. Oncoimmunology. 2018 Feb 14;7(5):e1426519.  2, David JM, et al. Oncoimmunology. 2017 Jul 13;6(10):e1349589. 3, Jochems C, et al. Oncotarget. 2017 Sep 8;8(43):75217-75231. 

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