M6766 | ERO1α inhibitor | Probechem Biochemicals

Chemical Structure : M6766

CAS No.: 696628-90-7

加入收藏

M6766 (M-6766)

货号: PC-25115Not For Human Use, Lab Use Only.

M6766 is a potent, selective inhibitor of endoplasmic reticulum oxidoreductase 1α (ERO1α) with IC50 of 1.4 uM and KD of 1.1 uM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

M6766 is a potent, selective inhibitor of endoplasmic reticulum oxidoreductase 1α (ERO1α) with IC50 of 1.4 uM and KD of 1.1 uM.
M6766 exhibits >70-fold selectivity over other tested enzymes, except ERO1β (IC50=7.2 μM).
M6766 binds to the FAD-binding pocket in ERO1α.
M6766 concentration-dependently inhibits granule secretion, αIIbβ3 integrin activation, Ca2+ mobilization, and platelet aggregation induced by various agonists, but it does not affect agonist-induced production of reactive oxygen species.
M6766 diminishes platelet accumulation on collagen-coated surfaces under arterial shear conditions.
M6766 decreases arterial thrombosis and infarct volume during ischemic stroke without prolonging tail bleeding times in mice.

物理化学性质&存储条件

分子量	360.44
分子式	C19H16N6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	11-((4-methyl-4H-1,2,4-triazol-3-yl)thio)-7,8,9,10-tetrahydrobenzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile

参考文献

1. Wang J, et al. Mol Ther. 2025 Jul 23:S1525-0016(25)00569-6.

M6766 (M-6766)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

M6766 (M-6766)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.