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首页-小分子抑制剂&激动剂-Others-Other Targets-M50054
M50054

Chemical Structure : M50054

CAS No.: 54135-60-3

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M50054 (M 50054)

货号: PC-49743Not For Human Use, Lab Use Only.

M50054 (M 50054) is a small molecule inhibitor of apoptosis (programmed cell death), inhibits soluble human Fas ligand-induced cell death of human Fasexpressing WC8 cells with IC50 of 67 ug/mL.

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5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

M50054 (M 50054) is a small molecule inhibitor of apoptosis (programmed cell death), inhibits soluble human Fas ligand-induced cell death of human Fasexpressing WC8 cells with IC50 of 67 ug/mL.
M50054 inhibits etoposide-induced cell death of U937 cells with IC50 of 130 ug/mL.
M50054 inhibits DNA fragmentation of U937 cells induced by etoposide in a dose-dependent manner (IC50=54ug/mL), also inhibits DNA fragmentation of WC8 cells induced by soluble human Fas ligand, inhibits cell death via inhibition of DNA fragmentation and phosphatidylserine exposure.
M50054 protects against apoptotic cell death via inhibition of caspase-3 activation.
M50054 (100 mg/kg, oral) inhibited the elevation of alanine aminotransferase and aspartate aminotransferase in a dose-dependent manner in anti-Fas-antibody-treated mice, significantly improved alopecia (hair loss) symptoms in chemotherapy-induced alopecia in newborn rats.

物理化学性质&存储条件

分子量 236.27
分子式 C13H16O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,2'-methylenebis (1,3-cyclohexanedione)

参考文献

1. Tsuda T, et al. Eur J Pharmacol. 2001 Dec 14;433(1):37-45.

2. Sîrbulescu RF, et al. Neuroscience. 2010 Dec 1;171(2):599-612.

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