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首页-小分子抑制剂&激动剂-Autophagy-ULK-M468-4456
M468-4456

Chemical Structure : M468-4456

CAS No.: 1358267-29-4

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M468-4456 (Compound U9)

货号: PC-25237Not For Human Use, Lab Use Only.

M468-4456 (Compound U9) is a small molecule inhibitor of serine/threonine kinase UNC-51-like kinase 1 (ULK1) with IC50 of 305 nM,

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

M468-4456 (Compound U9) is a small molecule inhibitor of serine/threonine kinase UNC-51-like kinase 1 (ULK1) with IC50 of 305 nM,
Compound U9 has a broad-spectrum anticancer effect, especially on A549 cells.
Compound U9 effectively inhibits autophagy and induces apoptosis in A549 cells.

物理化学性质&存储条件

分子量 444.58
分子式 C27H32N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(6-benzyl-2-ethyl-4-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-3(4H)-yl)-N-(3-phenylpropyl)acetamide

参考文献

1. Zhijia Li, et al. Int J Biol Macromol. 2025 Aug 4;321(Pt 3):146532.

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