M443 | ZAK inhibitor | ProbeChem Biochemicals

Chemical Structure : M443

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M443 (ZAK inhibitor M443)

货号: PC-70175Not For Human Use, Lab Use Only.

M443 (M 443) is a specific, irreversible inhibitor of MLK-related kinase MRK (ZAK), does not inhibit Bcr-Abl.

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生物&药学活性

M443 (M 443) is a specific, irreversible inhibitor of MLK-related kinase MRK (ZAK), does not inhibit Bcr-Abl.
M-443 effectively inhibits MRK downstream signals in primary medulloblastoma cells and prevents cell-cycle arrest induced by IR.
M-443 also inhibits radiation-induced activation of both p38 and Chk2.
M-443 achieves a synergistic increase in survival in an animal model of medulloblastoma.

物理化学性质&存储条件

分子量	589.623
分子式	C31H30F3N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-(1-acryloylpiperidin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

参考文献

1. Markowitz D, et al. Mol Cancer Ther. 2016 Aug;15(8):1799-808.

M443 (ZAK inhibitor M443)

生物&药学活性

物理化学性质&存储条件

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M443 (ZAK inhibitor M443)

生物&药学活性

物理化学性质&存储条件

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