M4284 |CAS:1373346-85-0 Probechem Biochemicals

Chemical Structure : M4284

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M4284 (M-4284;M 4284)

货号: PC-60900Not For Human Use, Lab Use Only.

M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay.

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1 g		Get quote

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生物&药学活性

M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay; reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously treating UTI, without notably disrupting the structural configuration of the gut microbiota; reduces UTI89 levels in the gut and urinary tracts of mice.

物理化学性质&存储条件

分子量	460.483
分子式	C23H28N2O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N3,N5,3'-trimethyl-4'-(((3S,4R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-[1,1'-biphenyl]-3,5-dicarboxamide

参考文献

1. Spaulding CN, et al. Nature. 2017 Jun 22;546(7659):528-532.

2. Jarvis C, et al. ChemMedChem. 2016 Feb 17;11(4):367-73.

3. Han Z, et al. J Med Chem. 2012 Apr 26;55(8):3945-59.

M4284 (M-4284;M 4284)

生物&药学活性

物理化学性质&存储条件

参考文献

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M4284 (M-4284;M 4284)

生物&药学活性

物理化学性质&存储条件

参考文献

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