M3686 | TEAD1 inhibitor | Probechem Biochemicals

Chemical Structure : M3686

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M3686 (M-3686)

货号: PC-23670Not For Human Use, Lab Use Only.

M3686 is a potent, selective TEAD1 inhibitor with IC50 of 51 nM in TEAD reporter assay, shows weaker binding to TEAD3, and negligible activity on TEAD2 and TEAD4.

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生物&药学活性

M3686 is a potent, selective TEAD1 inhibitor with IC50 of 51 nM in TEAD reporter assay, shows weaker binding to TEAD3, and negligible activity on TEAD2 and TEAD4.
M3686 potently inhibits cell viability against YAP-dependent NCI-H226 cell line with IC50 of 0.06 uM.
M3686 (3, 10, and 30 mg/kg) shows strong anti-tumor effects in the NCI-H226 xenograft model.

物理化学性质&存储条件

分子量	429.40
分子式	C21H18F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-(3-hydroxypyrrolidin-1-yl)(2-methyl-4-(4-(trifluoromethyl)phenyl)-2,4-dihydro-[1,2,3]triazolo[4,5-b]indol-7-yl)methanone

参考文献

1. Heinrich T, et al. J Med Chem. 2024 Dec 20. doi: 10.1021/acs.jmedchem.4c01949.

M3686 (M-3686)

生物&药学活性

物理化学性质&存储条件

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M3686 (M-3686)

生物&药学活性

物理化学性质&存储条件

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