M2698 | S6K/Akt inhibitor | Probechem Biochemicals

Chemical Structure : M2698

CAS No.: 1379545-95-5

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M2698 (MSC-2363318A, MSC2363318A, M 2698)

货号: PC-60433Not For Human Use, Lab Use Only.

M2698 (MSC2363318A) is a potent, selective, ATP-competitive, orally bioavailable and brain penetrant dual inhibitor of p70S6K and Akt1/3 with IC50 of 1 nM and 17 nM, respectively.

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5 mg	￥1780	In stock
10 mg	￥2880	In stock
25 mg	￥4980	In stock
50 mg	￥7880	In stock
100 mg		Get quote

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生物&药学活性

M2698 (MSC2363318A) is a potent, selective, ATP-competitive, orally bioavailable and brain penetrant dual inhibitor of p70S6K and Akt1/3 with IC50 of 1 nM and 17 nM, respectively.
M2698 displays relative selectivity against a panel of 264 kinases (only 6 kinases within 10-fold IC50 of p70S6K).
M2698 inhibits the phosphorylation of p70S6K1 and Akt substrates, S6 (IC50=11 nM) and GSK3β (IC50=17 nM) in MDA-MB-468 cells, shows proliferation inhibition of 9 breast cancer cell lines (IC50<2 uM).
M2698 inhibits growth of human breast cancer xenografted tumors in mice.

物理化学性质&存储条件

分子量	449.862
分子式	C21H19ClF3N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-((2-(azetidin-1-yl)-1-(4-chloro-3-(trifluoromethyl)phenyl)ethyl)amino)quinazoline-8-carboxamide

参考文献

1. Machl A, et al. Am J Cancer Res. 2016 Mar 15;6(4):806-18.

2. Previs RA, et al. J Natl Cancer Inst. 2017 Jul 1;109(7).

M2698 (MSC-2363318A, MSC2363318A, M 2698)

生物&药学活性

物理化学性质&存储条件

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M2698 (MSC-2363318A, MSC2363318A, M 2698)

生物&药学活性

物理化学性质&存储条件

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