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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-M1002
M1002

Chemical Structure : M1002

CAS No.: 823830-85-9

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M1002 (M 1002, M-1002)

货号: PC-24484Not For Human Use, Lab Use Only.

M1002 is a small molecule allosteric agonist of hypoxia-inducible factor-2 (HIF-2) with EC50 of 0.44 uM in luciferase reporter gene assays, enhances the affinity of HIF-2α and ARNT for transcriptional activation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

M1002 is a small molecule allosteric agonist of hypoxia-inducible factor-2 (HIF-2) with EC50 of 0.44 uM in luciferase reporter gene assays, enhances the affinity of HIF-2α and ARNT for transcriptional activation.
M1002 is capable of altering the conformation of Tyr281 of the HIF-2α PAS-B domain and enhancing the affinity of HIF-2α and ARNT.

物理化学性质&存储条件

分子量 394.29
分子式 C15H8F6N2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((3,5-Bis(trifluoromethyl)phenyl)amino)benzo[d]isothiazole 1,1-dioxide

参考文献

1. Yu Y, et al. Eur J Med Chem. 2021 Feb 5;211:112999.

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