M-110 |CAS:1395048-49-3 Probechem Biochemicals

Chemical Structure : M-110

CAS No.: 1395048-49-3

加入收藏

M-110 (M110)

货号: PC-43239Not For Human Use, Lab Use Only.

M-110 is a potent, selective inhibitor of PIM kinase family with preference for PIM-3 with IC50 of 0.047, 2.5 and 2.5 uM for PIM3, PIM1 and PIM2, respectively.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

M-110 is a potent, selective inhibitor of PIM kinase family with preference for PIM-3 with IC50 of 0.047, 2.5 and 2.5 uM for PIM3, PIM1 and PIM2, respectively.
M-110 dispplays excellent selectivity in a panel of 261 kinases.
M-110 inhibits the growth of DU-145 cells with IC50 of 0.9 uM, significantly reduces pSTAT3(Tyr705) expression without affecting the expression of STAT3.
M-110 also attenuates the IL-6-induced increase in pSTAT3(Tyr705), shows no effect on phosphorylation of STAT5 on Tyr694 in 22Rv1 cells.

物理化学性质&存储条件

分子量	445.9424
分子式	C22H28ClN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Pyridinecarboxylic acid, 2-[[3-(4-morpholinyl)propyl]amino]-, 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide

参考文献

1. Chang M, et al. Mol Cancer Ther. 2010 Sep;9(9):2478-87.

2. Siu A, et al. Oncotarget. 2011 Dec;2(12):1134-44.

M-110 (M110)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

M-110 (M110)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.