Lys05 |CAS:1391426-24-6 Probechem Biochemicals

Chemical Structure : Lys05

CAS No.: 1391426-24-6

加入收藏

Lys05 (Lys-05;Lys 05;Lys01 trihydrochloride;PS-1001)

货号: PC-60601Not For Human Use, Lab Use Only.

Lys05 (Lys01 trihydrochloride, PS-1001) is the water-soluble salt of Lys01, is a 10-fold more potent lysosomal autophagy inhibitor than hydroxychloroquine (HCQ), also is a Kir4.1 inhibitor.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Lys05 (Lys01 trihydrochloride, PS-1001) is the water-soluble salt of Lys01, is a 10-fold more potent lysosomal autophagy inhibitor than hydroxychloroquine (HCQ), also is a Kir4.1 inhibitor.
Lys05 shows IC50 values of 3.6, 3.8, 6 and 7.9 uM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay
Lys05 is more potently accumulates within and deacidifies the lysosome, resulting in impaired autophagy and tumor growth.
Lys05 enhances sunitinib-mediated suppression of clear cell ovarian carcinoma (CCOC) cell viability.
Lys05 is a potent, selective inhibitor of astrocytic inwardly rectifying potassium channel 4.1 (Kir4.1), inhibits inward and outward potassium currents with IC50 of 0.22 and 0.18 uM, respectively.
Lys05 preferentially inhibits the Kir4.1 channel over other Kir isoforms, displays selectivity against other classes of potassium channels, such as astrocyte-expressing TWIK1, THIK1, TREK1 and neuronal KCNQ2, KCNQ3 channels, as well as cardiac hERG channels.
A single dose of Lys05 reversed the Kir4.1-driven depression-like phenotype and exerted rapid-onset antidepressant actions in multiple canonical depression rodent models with efficacy comparable to that of (S)-ketamine.

物理化学性质&存储条件

分子量	549.75
分子式	C23H26Cl5N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N1-methyl-1,2-ethanediamine trihydrochloride

参考文献

1. McAfee Q, et al. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8.

2. Amaravadi RK, et al. Autophagy. 2012 Sep;8(9):1383-4.

3. DeVorkin L, et al. Mol Cancer Res. 2017 Mar;15(3):250-258.

4. Ndoye A, et al. Cancer Res. 2017 Nov 1;77(21):5873-5885.

Lys05 (Lys-05;Lys 05;Lys01 trihydrochloride;PS-1001)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Lys05 (Lys-05;Lys 05;Lys01 trihydrochloride;PS-1001)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.