Luvadaxistat (TAK-831, NBI-1065844)

Chemical Structure : Luvadaxistat

CAS No.: 1425511-32-5

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货号: PC-20902Not For Human Use, Lab Use Only.

Luvadaxistat (TAK-831, NBI-1065844) is a highly potent, selective D-amino acid oxidase (DAAO) inhibitor with IC50 of 14 nM against human recombinant DAAO enzyme.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Luvadaxistat (TAK-831, NBI-1065844) is a highly potent, selective D-amino acid oxidase (DAAO) inhibitor with IC50 of 14 nM against human recombinant DAAO enzyme.
TAK-831 (Luvadaxistat) inhibits the formation of H2O2, the co-product of D-serine catalysis, with an IC50 of 12 nM, in a cellular assay using CHO cells expressing recombinant human DAAO.
TAK-831 (Luvadaxistat) inhibits H2O2 formation with IC50 of 5.1 nM in CHO cells expressing recombinant mouse DAAO.
TAK-831 (Luvadaxistat) shows very little off-target activity when profiled in a comprehensive selectivity panel of enzyme and radioactivity binding.
TAK-831 (Luvadaxistat) caused a dose- and exposure-dependent blockade of PGM019260 binding in the cerebellum with ED50 of 0.93 mg/kg in enzyme occupancy studies in mice.
TAK-831 (Luvadaxistat) (3 mg/kg p.o.) significantly reverses a poly(I:C)-induced deficit, improves social behavior in the SI test in BALB/c animals.

物理化学性质&存储条件

分子量	284.24
分子式	C13H11F3N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-hydroxy-6-(4-(trifluoromethyl)phenethyl)pyridazin-3(2H)-one

参考文献

1. Fradley R, et al. Neurochem Res. 2023 Jun 8. doi: 10.1007/s11064-023-03956-2.