Luseogliflozin |CAS:898537-18-3 Probechem Biochemicals

Chemical Structure : Luseogliflozin

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Luseogliflozin (TS-071;TS071)

货号: PC-61383Not For Human Use, Lab Use Only.

A potent, selective, orally acitve SGLT2 inhibitor with IC50 of 2.26 nM, 1650-fold selectivity over SGLT1.

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生物&药学活性

Luseogliflozin (TS-071) is a potent, selective, orally acitve SGLT2 inhibitor with IC50 of 2.26 nM, 1650-fold selectivity over SGLT1.
Luseogliflozin (TS-071) exhibits a blood glucose lowering effect, excellent urinary glucose excretion properties, and promising PK profiles in vivo.
Luseogliflozin (TS-071) increases urinary glucose excretion in Zucker fatty rats and beagle dogs at doses of 0.3 and 0.03 mg/kg respectively.
Luseogliflozin (TS-071) improves glucose tolerance without stimulating insulin secretion and reduces hyperglycaemia in STZ-induced diabetic rats.

物理化学性质&存储条件

分子量	434.547
分子式	C23H30O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4R,5S,6R)-2-[5-[(4-ethoxyphenyl)methyl]-2-methoxy-4-methylphenyl]-6-(hydroxymethyl)thiane-3,4,5-trio

参考文献

1. Kakinuma H, et al. J Med Chem. 2010 Apr 22;53(8):3247-61.

2. Yamamoto K, et al. Br J Pharmacol. 2011 Sep;164(1):181-91.

Luseogliflozin (TS-071;TS071)

生物&药学活性

物理化学性质&存储条件

参考文献

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Luseogliflozin (TS-071;TS071)

生物&药学活性

物理化学性质&存储条件

参考文献

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