Lurasidone (SM-13496) | D2R antagonist | Probechem Biochemicals

Chemical Structure : Lurasidone

CAS No.: 367514-87-2

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Lurasidone (SM-13496, SM13496)

货号: PC-21083Not For Human Use, Lab Use Only.

Lurasidone (SM-13496) is an atypical antipsychotic compound with potent dopamine D2 (Ki =1.68 nM) and serotonin 5-HT2A (Ki=2.03 nM) receptor-blocking activities.

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200 mg	￥2980	In stock
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生物&药学活性

Lurasidone (SM-13496) is an atypical antipsychotic compound with potent dopamine D2 (Ki =1.68 nM) and serotonin 5-HT2A (Ki=2.03 nM) receptor-blocking activities.
Lurasidone (SM-13496) also has high affinities for serotonin 5-HT1A (Ki = 6.75 nM), 5-HT7 receptors (Ki = 0.495 nM), and α2C adrenoceptor (Ki = 10.8 nM), but only weak or negligible interactions with serotonin 5-HT2C, histamine H1, acetylcholine M1 receptors, and α1 adrenoceptor.
Lurasidone (SM-13496) significantly and dose-dependently reversed the MK-801-induced impairment of the passive-avoidance response.
Lurasidone (SM-13496) is superior to other antipsychotics in improving the MK-801-induced memory impairment.

物理化学性质&存储条件

分子量	492.68
分子式	C28H36N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione

参考文献

1. Ishiyama T, et al. Eur J Pharmacol. 2007 Oct 31;572(2-3):160-70.

Lurasidone (SM-13496, SM13496)

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Lurasidone (SM-13496, SM13496)

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