Lumiracoxib (COX-189) | COX-2 inhibitor | Probechem Biochemicals

Chemical Structure : Lumiracoxib

CAS No.: 220991-20-8

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Lumiracoxib (Prexige, COX-189)

货号: PC-20195Not For Human Use, Lab Use Only.

Lumiracoxib (COX-189) is a highly selective COX-2 inhibitor with IC50 of 0.14 uM in COX-2-expressing dermal fibroblasts, inhibits purified COX-2 with Ki of 0.06 uM, 50-fold selectivity over COX-1 (Ki=3 uM).

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10 mg	￥380	In stock
25 mg	￥680	In stock
50 mg	￥1180	In stock
100 mg	￥1880	In stock
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生物&药学活性

Lumiracoxib (COX-189) is a highly selective COX-2 inhibitor with IC50 of 0.14 uM in COX-2-expressing dermal fibroblasts, inhibits purified COX-2 with Ki of 0.06 uM, 50-fold selectivity over COX-1 (Ki=3 uM).
Lumiracoxib shows no inhibition of COX-1 at concentrations up to 30 microM (HEK 293 cells transfected with human COX-1).
Lumiracoxib shows IC50 of 0.13 uM a human whole blood assay, 515 fold over COX-1.
Ex vivo, lumiracoxib inhibited COX-2-derived production of prostaglandin E(2) (PGE(2)) in the lipopolysaccharide-stimulated rat air pouch with an ID(50) value of 0.24 mg kg(-1).
Lumiracoxib showed dose-dependent effect in rat models of hyperalgesia, oedema, pyresis and arthritis.

物理化学性质&存储条件

分子量	293.72
分子式	C15H13ClFNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-((2-chloro-6-fluorophenyl)amino)-5-methylphenyl)acetic acid

参考文献

1. Ronald Esser, et al. Br J Pharmacol. 2005 Feb;144(4):538-50.

Lumiracoxib (Prexige, COX-189)

生物&药学活性

物理化学性质&存储条件

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Lumiracoxib (Prexige, COX-189)

生物&药学活性

物理化学性质&存储条件

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