Lumateperone |CAS:313368-91-1 Probechem Biochemicals

Chemical Structure : Lumateperone

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Lumateperone (ITI-007)

货号: PC-70076Not For Human Use, Lab Use Only.

Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM).

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生物&药学活性

Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM); also shows affinity for D1; orally bioavailable and exhibits good antipsychotic efficacy in vivo.

Schizophrenia

Phase 3 Clinical

物理化学性质&存储条件

分子量	393.496
分子式	C24H28FN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one

参考文献

1. Li P, et al. J Med Chem. 2014 Mar 27;57(6):2670-82.

2. Snyder GL, et al. Psychopharmacology (Berl). 2015 Feb;232(3):605-21.

Lumateperone (ITI-007)

生物&药学活性

物理化学性质&存储条件

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Lumateperone (ITI-007)

生物&药学活性

物理化学性质&存储条件

参考文献

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