Lucerastat (NB-DGJ, ACT-434964) | GCS inhibitor | Probechem Biochemicals

Chemical Structure : Lucerastat

CAS No.: 141206-42-0

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Lucerastat (NB-DGJ, N-Butyldeoxygalactonojirimycin, ACT-434964, OGT-923)

货号: PC-61429Not For Human Use, Lab Use Only.

Lucerastat (NB-DGJ, ACT-434964) is a galactose analogue that is an UDP-glucose ceramide glucosyltransferase (UGCG/GCS) inhibitor (IC50=41.4 uM).

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5 mg	￥1480	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
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生物&药学活性

Lucerastat (NB-DGJ, ACT-434964) is a galactose analogue that is an UDP-glucose ceramide glucosyltransferase (UGCG/GCS) inhibitor (IC50=41.4 uM).
Lucerastat prevents glucosylceramide biosynthesis both in vitro and in mouse models of lysosome storage disorders, without affecting α-glucosidase I and II or β-glucocerebrosidase (IC50>1 mM).
Lucerastat shows potential as substrate reduction therapy for glycolipid storage disorders such as Gaucher disease and Fabry disease.

物理化学性质&存储条件

分子量	219.281
分子式	C10H21NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol

参考文献

1. Platt FM, et al. J Biol Chem. 1994 Oct 28;269(43):27108-14.

2. Andersson U, et al. Biochem Pharmacol. 2000 Apr 1;59(7):821-9.

3. Kasperzyk JL, et al. J Neurochem. 2004 May;89(3):645-53.

Lucerastat (NB-DGJ, N-Butyldeoxygalactonojirimycin, ACT-434964, OGT-923)

生物&药学活性

物理化学性质&存储条件

参考文献

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Lucerastat (NB-DGJ, N-Butyldeoxygalactonojirimycin, ACT-434964, OGT-923)

生物&药学活性

物理化学性质&存储条件

参考文献

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